松本 欣三

松本 欣三MATSUMOTO Kinzo

薬学部 センター／薬学教育推進センター

• 学位

  薬学博士

• 資格・免許

  薬剤師

• 所属学会

  日本薬理学会（名誉会員）、日本神経精神薬理学会（功労会員）、日本臨床中医漢方医学会（理事：神経薬理学分野）

• 専門分野

  漢方薬理学、神経薬理学

• 研究テーマ

  ・認知情動障害の病態生理の解明と漢方薬をはじめとした伝統薬物による実験的治療
  ・発達障害の病因解明と予防・治療を志向した天然薬物研究

業績

• （著書）

  1. 釣藤鈎アルカロイドの薬理作用（「アルカロイドの科学」(高山廣光編、化学同人）を分担執筆)

  2. Memory/Learning, Dementia and Kampo（Herbal Medicines New Horizons, ed. by Inui A., Humana Press）

• （原著論文）

  1. Le X.T., Nguyen T.L.T., Nguyen P.T., Van T.N., Van H.N., Pham H.T.N., Matsumoto K. Anti-hypertensive effects of Callisia fragrans extract on reno-vascular hypertensive rats, Clin. Exp. Hypertens., 44: 411-418, 2022.

  2. Nguyen H.T., Le X.T., Nguyen T.V., Pham H.T.N., Nguyen K.M., Matsumoto K. Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum in olfactory bulbectomized mice, J Nat. Med. 76: 621-633, 2022.

  3. Araki R., Tachioka H., Kita A., Fujiwara H., Toume K., Matsumoto K., Yabe T. Kihito prevents corticosterone-induced brain dysfunctions in mice, J Tradit Complement Med, 11: 513-519, 2021.

  4. Le X.T., Nguyen H.T., Nguyen T.V., Pham H.T.N., Nguyen P.T., Phung H.N., Nguyen K.M., Nguyen B.V., Matsumoto K. Ocimum sanctum Linn. Extract improves cognitive deficits in olfactory bulbectomized mice via the enhancement of central cholinergic systems and VEGF expression, Evid. Based Complement. Alternat. Med. 2021, Article ID 6627648.

  5. Chulikhit Y., Sukhano W., Daodee S., Putalun W., Wongpradit R., Khamphukdee C., Umehara K., Noguchi H., Matsumoto K., Monthakantirat O. Effects of Pueraria candollei var mirifica (Airy Shaw and Suvat.) Niyomdham on ovariectomy-induced cognitive impairment and oxidative stress in the mouse brain, Molecules 26 (11), 3442, 2021.

  6. Pham H.T.N., Tran H.N., Le X.T., Do H.T., Nguyen T.T. Yoshida H., Yamaguhi M., Folk W.R., Matsumoto K. Ilex kudingcha C.J. Tseng mitigates phenotypic characteristics of human autism spectrum disorders in a Drosophila melanogaster rugose mutant, Neurochem. Res. 46(8), 1995–2007, 2021.

  7. Doan D.X., Sun S., Omar A.M., Nguyen D.T., Hoang A.L.T., Fujiwara H., Matsumoto K., Pham H.T.N., Awale S. Chemical constituents and absolute configuration of megastigmanes’ isolated from Sedum sarmentosum Bunge, Natural Product Res. 2020 (DOI: 10.1080/14786419.2020.1834549)

  8. Pham H.T.N., Tran H.N., Nguyen P.T., Le X.T. , Nguyen K.M., Phan S.V., Yoneyama M., Ogita K., Yamaguchi T., Folk W.R., Yamaguchi M., Matsumoto K. Bacopa monnieri (L.) Wettst. improves memory performance via promotion of neurogenesis in the hippocampal dentate gyrus of adolescent mice, Int. J. Mol. Sci. 21 (9): 3365, 2020.

  9. Tantipongpiradet A, Monthakantirat O, Vipatpakpaiboon O, Khampukdee C, Umehara K, Noguchi H, Fujiwara H, Matsumoto K, Sekeroglu N, Kijjoa A, Chulikhit Y. Effects of puerarin on the ovariectomy-induced depressive-like behavior in ICR mice and its possible mechanism of action. Molecules 24(24), 4568, 2019.

  10. Pham HTN, Phan SV, Tran HN, Phi XT, Le XT, Nguyen KM, Fujiwara H, Yoneyama M, Ogita K, Yamaguchi T, Matsumoto K. Bacopa monnieri (L.) Wettst. ameliorates cognitive deficits caused in a trimethyltin-induced neurotoxicity model mice. Biol. Pharm. Bull. 42, 1384–1393, 2019.

  11. Guo Q-Y, Ebihara K, Fujiwara H, Toume H, Awale S, Araki R, Yabe T, Dong E, Matsumoto K. Kami-shoyo-san ameliorates sociability deficits in ovariectomized mice, a putative female model of autism spectrum disorder, via facilitating dopamine D₁ and GABA_A receptor functions. J. Ethnopharmacol. 236, 231–239, 2019.

  12. Fujiwara H, Yoshida J, Dibwe DF, Awale S, Hoshino H, Kohama H, Arai H, Kudo Y, Matsumoto K. Orengedokuto and san’oshashinto improve memory deficits by inhibiting age-dependent GSK-3β activation and subsequent CRMP2 phosphorylation in senescence-accelerated prone 8 mice. J. Tradit. Complement. Med. 9(4), 328-335, 2019.

  13. Guo Q-Y, Ebihara K, Fujiwara H, Toume H, Dibwe DF, Awale S, Araki R, Yabe T, Matsumoto K. Kami-shoyo-san ameliorates ASD-like behaviors by inhibiting allopregnanolone biosynthesis in the brain via dopaminergic and, in part, GABAergic mechanisms. PLOS One 14(1), e0211266, 2019.

  14. Fujiwara H., Tsushima R., Okada R., Awale S., Araki R., Yabe T., Matsumoto K. Sansoninto, a traditional herbal medicine, ameliorates behavioral abnormalities and down-regulation of early growth response-1 expression in mice exposed to social isolation stress. J. Tradit. Complemen.t Med. 8, 81-88, 2018.

  15. Hiraki Y, Araki R, Fujiwara H, Ago Y, Tanaka T, Toume K, Matsumoto K, Yabe T. Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice. J. Pharmacol. Sci. 139(2), 72-76, 2018.

  16. Kimura K, Matsumoto K, Ohtake H, Oka J-I, Fujiwara H. Endogenous acetylcholine regulates the expression levels of neuronal and astrocytic vascular endothelial growth factor (VEGF) via different acetylcholine receptor mechanisms. Neurochem. Int. 118, 42-51, 2018.

  17. Sasaki-Hamada S, Suzuki A, Ueda Y, Matsumoto K, Oka JI. Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice. J. Pharmacol. Sci. 133: 110-113, 2017.

  18. Fujiwara H, Yaoyu H, Ebihara K, Awale S, Araki R, Yabe T, Matsumoto K. Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice, BMC Complement. Altern. Med. 17(1), 195, 2017.

  19. Sasaki-Hamada S, Suzuki A, Sanai E, Matsumoto K, Oka J-I. Neuroprotection by chotosan, a Kampo formula, against glutamate excitotoxicity involves the inhibition of GluN2B-, but not GluN_2A-containing NMDA receptor activation in primary cultured cortical neurons. J. Pharmacol. Sci. 135, 134-137, 2017.

  20. Ebihara K, Fujiwara H, Awale S, Fita Dibwe D, Araki R, Yabe T, Matsumoto K. Decrease in endogenous brain allopregnanolone induces autism spectrum disorder (ASD)-like behavior in mice: a novel animal model of ASD. Behav. Brain Res. 334, 6-15, 2017.

• （総説等）

  1. Matsumoto K, Fujiwara H, Araki R, Yabe T. Post-weaning social isolation of mice: a putative animal model of developmental disorders. J. Pharmacol. Sci. 141, 111-118, 2019.

  2. Ueoka I, Pham HNT, Matsumoto K, Yamaguchi M. Autism spectrum disorder: modeling with Drosophila, rodents and C. elegans [Review]. Int. J. Mol. Sci. 20, 4071, 2019.

• （学会発表）

  1. Kinzo Matsumoto (Invited Keynote Lecture), An experimental approach from Japanese Kampo medicines to autism spectrum disorder (ASD) therapy in an allopregnanolone-deficient model, 7th International Mediterranean Symposium on Medicinal and Aromatic Plants, Nov. 18-20, 2021 Izmir, Turkey

  2. Kinzo Matsumoto (Invited), Anti-dementia effect of Chotosan, a traditional Chinese and Kampo medicine, and its putative mechanisms involving a linkage between cholinergic and vascular endothelial growth factor (VEGF) systems, The 2nd International Qi-Blood Conference, Sept. 13-15, 2019, Beijing, China

  3. Kinzo Matsumoto (Invited), Neuropharmacology of traditional Kampo medicines focusing on developmental disorders, World Frontiers Forum on Traditional Chinese Medicine, July 7-3, 2019, Pingsha, China

  4. 松本欣三（招待講演），記憶の病と漢方薬，2019 Academic Conference of Inner Mongolia Mongolian Medical Associatation Enchephalopathy Professional Committee，June 21-23, 2019, Huhhot，Inner Mongol，China

  5. Kinzo Matsumoto，Hironori Fujiwara (Invited)，An experimental approach using a neurosteroid deficient mouse model from Kampo medicines to autism spectrum disorder (ASD) therapy，第92回日本薬理学会JPSサテライトシンポジウム，2019年3月，大阪

  6. Kinzo Matsumoto (Invited)，Application and Scientific Support of Kampo Medicine，Thai National Conference on Herbs – Champion Products: Samunprai Thai (Thai herb) for sustainable economy，Apr. 4-5, 2018, Bangkok, Thailand

  7. 松本欣三（招待講演），和漢薬研究を科学知化する必要条件：「記憶と心の病と和漢薬」研究を中心に，第35回和漢医薬学会学術大会，2018年9月1－2日，岐阜

• （社会貢献）

  1. 松本欣三（講義），漢方の基本を学ぶ：発達障害の緩和治療に向けた漢方薬からの実験的アプローチ，2020年度第一薬科大学薬剤師生涯学習講座，2021年1月19日，第一薬科大学

  2. 松本欣三（市民教育），こころと記憶の病と和漢薬，富山市民大学講座，2018年7月13日，富山市民プラザ，富山

  3. 松本欣三 （教育講演），マウスから学ぶ”こころと記憶の病”と和漢薬，第60回富山県理科教育研究発表会記念講演，2017年11月22日，富山県総合教育センター，富山