山脇 洋輔

山脇 洋輔YAMAWAKI Yosuke

薬学部 薬学科／薬物治療学分野

• 学位

  博士（医薬学）

• 所属学会

  日本薬学会、日本薬理学会、日本神経精神薬理学会、日本神経科学会

• 専門分野

  精神薬理学

• 研究テーマ

  全身炎症によるグリア細胞を介した中枢機能障害の機序解明

業績

• （原著論文）

  1. Expression of PRIP, a phosphatidylinositol 4,5-bisphosphate binding protein, attenuates PI3K/AKT signaling and suppresses tumor growth in a xenograft mouse model. Maetani Y, Asano S, Mizokami A, Yamawaki Y, Sano T, Hirata M, Irifune M, Kanematsu T. Biochem Biophys Res Commun. 552:106-113 (2021)

  2. Possible Involvement of MyD88 in Regulating Stress Response in Mice. Hosoi T, Yamawaki Y, Kimura H, Honda S, Ozawa K. Front. Neurosci. 15:62144 (2021)

  3. IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier. Furutama D, Matsuda S, Yamawaki Y, Hatano S, Okanobu A, Memida T, Oue H, Fujita T, Ouhara K, Kajiya M, Mizuno N, Kanematsu T, Tsuga K, Kurihara H. 10(10):679, Brain Sci. (2020)

  4. Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study. Yoshino A, Okamoto Y, Sumiya Y, Okada G, Takamura M, Ichikawa N, Nakano T, Shibasaki C, Aizawa H, Yamawaki Y, Kawakami K, Yokoyama S, Yoshimoto J, Yamawaki S. Front Hum Neurosci., 14:165. (2020)

  5. Anti-inflammatory effects of miRNA-146a induced in adipose and periodontal tissues. Sanada T, Sano T, Sotomaru Y, Alshargabi R, Yamawaki Y, Yamashita A, Matsunaga H, Iwashita M, Shinjo T, Kanematsu T, Asano T, Nishimura F. Biochem Biophys Rep. 22:100757 (2020)

  6. Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress. Nozaki K, Ito H, Ohgidani M, Yamawaki Y, Sahin EH, Kitajima T, Katsumata S, Yamawaki S, Kato TA, Aizawa H. Neuropharmacology. 162:107835 (2020)

  7. Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.　Yamawaki　Y, Shirawachi　S, Mizokami　A, Nozaki K, Ito H, Asano S, Oue K, Aizawa H, Yamawaki S, Hirata M, Kanematsu T. Neurochem. Int. 131:104563 (2019)

  8. Phospholipase C-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow. Asano S, Ikura Y, Nishimoto M, Yamawaki Y, Hamao K, Kamijo K, Hirata M, Kanematsu T. Sci Rep. 9(1):12729.　（2019）

  9. Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.　Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T. Cell Rep. 6(12): 3221-3230.e3 (2019)

  10. Immobilization stress induces XBP1 splicing in the mouse brain.　Hosoi T, Kimura H, Yamawaki Y, Mori K, Ozawa K.　 Biochem. Biophys. Res. Commun.508(2)：516-520 (2019)

  11. Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats.　Yamawaki Y, Nishida M, Harada K, Akagi H. Data Brief. 18:496-500 (2018)

  12. Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates.　Lotan A, Lifschytz T, Wolf G, Keller S, Ben-Ari H, Tatarsky P, Pillar N, Oved K, Sharabany J, Merzel TK, Matsumoto T, Yamawaki Y, Mernick B, Avidan E, Yamawaki S, Weller A, Shomron N, Lerer B. Mol. Psychiatry 23(6): 1432-1445 (2018)

  13. Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice.　Yamawaki Y, Yoshioka N, Nozaki K, Ito H, Oda K, Harada K, Shirawachi S, Asano S, Aizawa H, Yamawaki S, Kanematsu T, Akagi H.　Brain Res. 1680:13-38 (2018)

  14. Suppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signalling.　Asano S, Taniguchi Y, Yamawaki Y, Gao J, Harada K, Takeuchi H, Hirata M, Kanematsu T.　Sci. Rep. 14;7(1):5408 (2017)

  15. General anesthetic actions on GABAA receptors in vivo are reduced in phospholipase C-related catalytically inactive protein knockout mice.　Hayashiuchi M, Kitayama T, Morita K, Yamawaki Y, Oue K, Yoshinaka T, Asano S, Harada K, Kang Y, Hirata M, Irifune M, Okada M, Kanematsu T. J. Anesth. 31(4):531-538 (2017)

  16. Phospholipase C-related catalytically inactive protein-knockout mice exhibit uncoupling protein 1 upregulation in adipose tissues following chronic cold exposure.　Oue K, Yamawaki Y, Asano S, Mizokami A, Hirata M, Irifune M, Kanematsu T. J. Oral Biosci. 59(2):108-112 (2017)

  17. Immobilization stress-induced anorexia is mediated independent of MyD88.　Hosoi T, Yamawaki Y, Kimura H, Ozawa K. Neuroreport 27(13):974-7 (2016)

  18. Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by β-Adrenergic Receptors in Brown Adipocytes.　Oue K, Zhang J, Harada-Hada K, Asano S, Yamawaki Y, Hayashiuchi M, Furusho H, Takata T, Irifune M, Hirata M, Kanematsu T. J. Biol. Chem. 291(8):4185-96 (2016)

  19. Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: an exploratory magnetic resonance imaging voxel-based morphometry study.　Machino A, Kunisato Y, Matsumoto T, Yoshimura S, Ueda K, Yamawaki Y, Okada G, Okamoto Y, Yamawaki S. J. Affect. Disord. 168:229-35 (2014)

  20. PMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H(1) receptor.　Mizuguchi H, Miyagi K, Terao T, Sakamoto N, Yamawaki Y, Adachi T, Ono S, Sasaki Y, Yoshimura Y, Kitamura Y, Takeda N, Fukui H. Sci. Rep. 2:916 (2012)

  21. Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus.　Yamawaki Y, Fuchikami M, Morinobu S, Segawa M, Matsumoto T, Yamawaki S. World J. Biol. Psychiatry 13(6):458-67 (2012)

  22. MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus.　Yamawaki Y, Kimura H, Hosoi T, Ozawa K. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298(2): R403-10 (2010)

• （総説等）

  1. Phospholipase C-related catalytically inactive protein: a novel signaling molecule for modulating fat metabolism and energy expenditure.　Kanematsu　T, Oue K, Okumura T, Harada K, Yamawaki Y, Asano S, Mizokami A, Irifune M, Hirata M. J. Oral Biosci. 61(2):65-72 (2019)

  2. Phospholipase C-related catalyticallyinactive protein can regulate obesity, a state of peripheral inflammation.　Yamawaki Y, Oue K, Shirawachi S, Asano S, Harada K, Kanematsu T. Jpn. Dent. Sci. Rev. 53(1):18-24 (2017)

  3. The potential use of histone deacetylase inhibitors in the treatment of depression.　Fuchikami M, Yamamoto S, Morinobu S, Okada S, Yamawaki Y, Yamawaki S. Prog Neuropsychopharmacol Biol. Psychiatry, 64:320-4

• （学会発表）

  1. 三環系抗うつ薬イミプラミンの歯周病原細菌由来LPSが誘導するミクログリアによる神経障害抑制効果　第62回 歯科基礎医学会学術大会　2020年9月　オンライン

  2. Possible involvement of MEF2D upregulation mediated by AKT-GSK3β signal in imipramine-enhanced interleukine-10 expression in astrocyte under inflammatory state　CINP 2021 Virtual World Congress　2021年2月　オンライン

• （競争的資金獲得状況）

  1. （代表）日本学術振興会 科学研究費助成事業 基盤研究(C) 2021年4月 – 2024年3月

     アディポカインによるミクログリア活性化を介した肥満におけるストレス脆弱性形成機構

     山脇　洋輔, 小山　進

  2. （分担）日本学術振興会 科学研究費助成事業 基盤研究(C) 2020年4月 – 2023年3月

     脳内報酬系レプチン－ドパミン連関を介した肥満における過食形成機序

     小山 進, 山脇 洋輔

  3. （代表）文部科学省:科学研究費補助金(基盤研究(C)) 2017年4月 – 2020年3月

     歯周病による中枢機能障害の基盤となるストレス応答性亢進機構の解明研究

     山脇 洋輔

  4. （分担）文部科学省科学研究費補助金基盤研究（C) 2016年4月 – 2019年3月

     膜リン脂質代謝変調がもたらす癌増悪メカニズムの解明研究

     兼松 隆、山脇　洋輔

  5. （代表）文部科学省 科学研究費補助金(若手研究(B)) 2015年4月 – 2017年3月

     ミクログリアを標的としたうつ病治療に関わるストレス応答機構の解明研究

     山脇 洋輔

  6. （分担）文部科学省 挑戦的萌芽研究 2014年4月 – 2016年3月

     脂肪細胞の分化と脱分化制御の分子基盤解明研究

     兼松 隆、山脇洋輔

  7. （代表）文部科学省 科学研究費補助金(若手研究(B)) 2013年4月 – 2015年3月

     ストレス脆弱性形成機構としてのミクログリアのエピジェネティクスに関する研究

     山脇 洋輔