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白 谷

• 薬学教育における学習成果の可視化手法の開発
• 大環状芳香族化合物を用いた光機能材料の開発

松 本

• 認知障害と発達障害の発症機構および漢方薬・天然薬物を用いた治療法の開発

村 山

• ビタミンの生合成経路に関する研究
• PM2.5による健康への影響

清 水

• 教育手法の有効性に関する研究
• うつ病に関する研究

古 賀

• 機能性シクロデキストリン誘導体および機能性環状化合物に関する研究
• NMRを用いた機能性分子の分子挙動解析に関する研究
• 食品や医薬品などに含まれる機能性糖類等に関する調査研究

松 延

• 薬学教育に対するデータ解析

 

1. 保健機能食品およびいわゆる健康食品の摂取状況と医薬品との相互作用に関する意識調査
   食品化学学会誌、31(1), 2024. (In press).
   城戸克己、山田涼太、清水裕一朗、林田諭、廣村信、片岡裕美、飯田浩子、田鶴谷 (村山)惠子
2. 粗大および微小大気粒子状物質がマスト細胞株に及ぼす影響
   片岡裕美、田中かおり、村山（田鶴谷）惠子、山下沢、西川淳一
   YAKUGAKU ZASSHI, 143, 159-170, 2023
3. Three-in-one: Miniature Models of Natural Acyl-transfer Systems Enable Vector-selective Reaction on the Primary Side of Cyclodextrins, T. Tominaga, K. Fukuda, K. Koga, M. Fukudome, and D.-Q. Yuan, Chemistry – A European Journal, 28(8), https://doi.org/10.1002/chem.202103940 (2022).
4. Cytotoxic effects of water-soluble extracts of coarse and fine atmospheric particulate matter on mast cell lines.
   Hiromi Kataoka, Kaori Tanaka, Keiko Tazuya-Murayama, Taku Yamashita, Jun-ichi Nishikawa.
   Biol. Pharm. Bull.　44(1), 57-62, 2021
5. Effects of chronic glucocorticoid receptor stimulation on circadian locomotor activity and serotonergic neurotransmission in the basolateral amygdala of rats. N. Shimizu, C. Hara., Biological and Pharmaceutical Bulletin, 43, 1279-1282, (2020).
6. Understanding a student’s academic ability to pass the national examination for pharmacists with the pass/fail prediction model. N. Shimizu, H. Inoue, C. Matsunobu. Y. Tsubaki, T. Shiratani, Japanese Journal of Pharmaceutical Education., 3, (2019).
7. Risk evasion and the economic impact of pharmaceutical intervention by community pharmacists. H. Koguchi, N. Sugimoto, T. Mitsuyasu, C. Matsunobu, T. Shiratani, T. Ikeuchi, S. Kaneshige,　K. Ogata, H. Kamimura, Japanese pharmacology and therapeutics, 47,375-382(2019).
8. 食品による生薬製剤のマスキング効果 城戸克己, 廣瀬恵美, 片岡裕美, 増田寿伸, 田鶴谷（村山）惠子 日本食品化学学会誌, 26(1), 68 -76 (2019)
9. Matsumoto K, Fujiwara H, Araki R, Yabe T. Post-weaning social isolation of mice: a putative animal model of developmental disorders [Review]. J. Pharmacol. Sci. 141, 111-118, 2019.
10. Tantipongpiradet A, Monthakantirat O, Vipatpakpaiboon O, Khampukdee C, Umehara K, Noguchi H, Fujiwara H, Matsumoto K, Sekeroglu N, Kijjoa A, Chulikhit Y. Effects of puerarin on the ovariectomy-induced depressive-like behavior in ICR mice and its possible mechanism of action. Molecules 24(24), 4568, 2019.
11. Ueoka I, Pham HNT, Matsumoto K, Yamaguchi M. Autism spectrum disorder: modeling with Drosophila, rodents and C. elegans [Review]. International Journal of Molecular Sciences 20, 4071, 2019.
12. Pham HTN, Phan SV, Tran HN, Phi XT, Le XT, Nguyen KM, Fujiwara H, Yoneyama M, Ogita K, Yamaguchi T, Matsumoto K. Bacopa monnieri (L.) Wettst. ameliorates cognitive deficits caused in a trimethyltin-induced neurotoxicity model mice. Biol Pharm Bull. 42, 1384–1393, 2019.
13. Guo Q-Y, Ebihara K, Fujiwara H, Toume H, Awale S, Araki R, Yabe T, Dong E, Matsumoto K. Kami-shoyo-san ameliorates sociability deficits in ovariectomized mice, a putative female model of autism spectrum disorder, via facilitating dopamine D1 and GABAA receptor functions. J. Ethnopharmacol. 236, 231–239, 2019.
14. Fujiwara H, Yoshida J, Dibwe DF, Awale S, Hoshino H, Kohama H, Arai H, Kudo Y, Matsumoto K. Orengedokuto and san’oshashinto improve memory deficits by inhibiting age-dependent GSK-3β activation and subsequent CRMP2 phosphorylation in senescence-accelerated prone 8 mice. J Tradit Complement Med. 9(4), 328-335, 2019.
15. Guo Q-Y, Ebihara K, Fujiwara H, Toume H, Dibwe DF, Awale S, Araki R, Yabe T, Matsumoto K. Kami-shoyo-san ameliorates ASD-like behaviors by inhibiting allopregnanolone biosynthesis in the brain via dopaminergic and, in part, GABAergic mechanisms. PLOS One14(1), e0211266, 2019.
16. 水質がウズ煎液中のアコニチン型ジエステルアルカロイド量に及ぼす影響.笛木司、別府正志、牧野利明、柴山周乃他.日本東洋医学雑誌.69(4):336-345、2018
17. Establishment of pass/fail prediction model based on Support Vector Machine. N. Shimizu, H. Inoue, C. Matsunobu, E. Kohro, Y. Tsubaki, T. Shiratani, Japanese Journal of Pharmaceutical Education., 2, 141-147, (2018).
18. 海洋性ピコプランクトンによるビタミンの産生と相互利用 田鶴谷（村山）惠子, 廣村信 ビタミン, 92(3), 132-135 (2018)
19. Fujiwara H., Tsushima R., Okada R., Awale S., Araki R., Yabe T., Matsumoto K. Sansoninto, a traditional herbal medicine, ameliorates behavioral abnormalities and down-regulation of early growth response-1 expression in mice exposed to social isolation stress. J Tradit Complement Med. 8, 81-88, 2018.
20. Araki R, Tohme K, Fujiwara H, Matsumoto K, Yabe T. Polygalae Radix extract ameliorates behavioral and neuromorphological abnormalities in mice treated chronically with corticosterone. Traditional & Kampo Medicine 5, 89-97, 2018.
21. Hiraki Y, Araki R, Fujiwara H, Ago Y, Tanaka T, Toume K, Matsumoto K, Yabe T. Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice. J. Pharmacol. Sci. 139(2), 72-76, 2018.
22. Kimura K, Matsumoto K, Ohtake H, Oka J-I, Fujiwara H. Endogenous acetylcholine regulates the expression levels of neuronal and astrocytic vascular endothelial growth factor (VEGF) via different acetylcholine receptor mechanisms. Neurochem Int. 118, 42-51, (2018).
23. PM2.5中の水溶性成分がマスト細胞株の脱顆粒に及ぼす影響 片岡裕美、中村智美、田鶴谷（村山）惠子、山下沢、西川淳一 大気環境学会誌、52(1)、12-18 (2017).
24. 古細菌のチアミン生合成経路の生化学的研究 林麻利亜、田鶴谷（村山）惠子、野坂和人 ビタミン(Vitamins (Japan)，91(38-47),　(2017)
25. Sasaki-Hamada S, Suzuki A, Ueda Y, Matsumoto K, Oka JI. Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice. J. Pharmacol. Sci. 133: 110-113, 2017.
26. Yokozawa T, Park CH, Matsumoto K. Scientific evidence for therapeutic effects of Chinese prescription Kangen-karyu from pre-clinical animal experiments [Review]. Drug Discov. Ther. 11(1), 6-14, 2017.
27. Fujiwara H, Yaoyu H, Ebihara K, Awale S, Araki R, Yabe T, Matsumoto K. Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice, BMC Complement Altern Med. 17(1), 195, 2017.
28. Sasaki-Hamada S, Suzuki A, Sanai E, Matsumoto K, Oka J-I. Neuroprotection by chotosan, a Kampo formula, against glutamate excitotoxicity involves the inhibition of GluN2B-, but not GluN2A-containing NMDA receptor activation in primary cultured cortical neurons. J. Pharmacol. Sci. 135, 134-137, 2017.
29. Awale S, Tawila AM, Dya Fita Dibwe, Ueda J-Y, Sun S, Athikomkulchai S, Balachandran C, Saiki I, Matsumoto K, Esumi H. Highly oxygenated antiausterity agents from the leaves of Uvaria dac. Bioorg Med Chem Lett. 27(9), 1967-1971, 2017.
30. Dibwe DF, Sun S, Ueda JY, Balachandran C, Matsumoto K, Awale S. Discovery of potential antiausterity agents from the Japanese cypress Chamaecyparis obtuse. Bioorg Med Chem Lett. 27(21), 4898-4903, 2017.
31. Ebihara K, Fujiwara H, Awale S, Fita Dibwe D, Araki R, Yabe T, Matsumoto K. Decrease in endogenous brain allopregnanolone induces autism spectrum disorder (ASD)-like behavior in mice: a novel animal model of ASD. Behav. Brain Res. 334, 6-15, 2017.
32. Kijima Y, Hayashi M, Yamada K., Tazuya-Murayama K. The biosynthesis of the pyrimidine moiety of thiamin in Halobacterium salinarum J Nutr. Sci. Vitaminol., 62(2),130-133, 2016
33. 张伯礼教授临床用对（队）药经验谈.郑文科、柴山周乃、江丰.天津中医药、（8）：449-452. 2016
34. Araki R, Nishida S, Hiraki Y, Li F, Matsumoto K, Yabe T. Kamikihito Ameliorates Lipopolysaccharide-Induced Sickness Behavior via Attenuating Neural Activation, but Not Inflammation, in the Hypothalamic Paraventricular Nucleus and Central Nucleus of the Amygdala in Mice. Biol Pharm Bull. 39(2), 289-94, 2016.
35. Nguyen HX, Nguyen NT, Dang PH, Thi PH, Nguyen MTT, Can MV, Dibwe D-F, Uedad J-Y, Matsumoto K, Awale S. A New Cassane-type Diterpene from the Seed of Caesalpinia sappan. Natural Product Comm. 11, 723-724, 2016.
36. Araki R, Hiraki Y, Nishida S, Kuramoto N, Matsumoto K, Yabe T. Epigenetic regulation of dorsal raphe GABAB1a associated with isolation-induced abnormal behaviors in mice. Neuropharmacology 101, 1-12, 2016.
37. Matsumoto K, Fujiwara H. Memory/Learning, Dementia and Kampo (in: Herbal Medicines New Horizons, Ed. Akio Inui), Methods in Pharmacology and Toxicology (Series title) (264pages, DOI: 10.1007/978-1-4939-4002-8), 2016, Sep. 22 Humana Press
38. The biosynthesis of the thiazole moiety of thiamin in the archaeon, Halobacterium salinarum. Hayashi M, Kijima Y, Tazuya-Murayama K, Yamada K. J. Nutr. Sci. Vitaminol., 61(3), 270-274, 2015.
39. Effect of adenosine system in the action of oseltamivir on behavior in mice.H. Uchiyama, M. Hiromura, T. Shiratani, H. Kuroki, S. Honda, K. Kosako, S. Soeda, K. Inoue, A. Toda, Neuroscience Letters 599(2015)7-11.
40. Splenectomy modifies hyperactive states of the dopaminergic system induced by morphine in C57BL/6J-bg(J)/bg(J) (beige-J) mice. Funada M, Maeda J, Tsuda Y, Komiya S, Shimizu N, Kamei J, Suzuki T. Eur J Pharmacol. 2014. 742: 89-93.
41. Enzymatic and structural characterization of an archaeal thiamin phosphate synthase. Biochim Biophys Acta.  Hayashi M, Kobayashi K, Esaki H, Konno H, Akaji K, Tazuya K, Yamada K, Nakabayashi T, Nosaka K. , 1844(4):803-9 (2014)
42. 酵母のチアミン生合成経路に関するもう1つの自殺酵素Thi5: 田鶴谷(村山)惠子，林　麻利亜，山田　和子, ビタミン 88(3),161-164 (2014)
43. Involvement of dopamine D2 receptor signal transduction in the discriminative stimulus effects of the κ-opioid receptor agonist U-50,488H in rats. Mori T, Yoshizawa K, Ueno T, Nishiwaki M, Shimizu N, Shibasaki M, Narita M, Suzuki T. Behav. Pharmacol. 2013; 24: 275-281.
44. Involvement of serotonin receptor mechanisms in the discriminative stimulus effects of ketamine in rats. Yoshizawa K, Mori T, Ueno T, Nishiwaki M, Shibasaki M, Shimizu N, Narita M, Suzuki T. J. Pharmacol. Sci.; 121: 237-241(2013).