科目ごとのオフィスアワーはシラバスを確認してください

錠剤・坐剤・貼付剤等の製剤は患者の薬物治療が有効かつ安全にそして利便性があるように設計されたものです。薬学で学ぶ化学・物理・生物等の知識を生かしDDS製剤の開発のための研究をしています。また、薬物－薬物間あるいは薬物－食物間相互作用等に関する体内動態の研究を行っています。

今 井

1. Ohura K, Nakada Y, Imai T, Biconversion and P-gp-mediated transport of depot flufenazine prodrugs after intramuscular injection., J. Pharm. Sci. 112 (2023) DOI:https://doi.org/10.1016/j.xphs.2023.03.018
2. Imai T, Isozaki M, Ohura K, Esterase involved in the rapid bioconversion of esmolol after intravenous injection in humans. Biol. Pharm. Bull., 45(10), 1544-1552 (2022)
3. Nakatani Y, Zhengmao Y Ishizue Y, Higashi T, Imai T, Fujii I, and.Michigami M, “Human and Mouse Cross-reactive” Albumin-binding Helix-loophelix Peptide Tag for Prolonged Bioactivity of Therapeutic Proteins., Mol. Pharm. 2022 May 28. doi: 10.1021/acs.molpharmaceut.2c00106
4. Hassan Md. M, Mohammed AFA, Elamin KM, Devkota HP, Ohno Y, Motoyama K, Higashi T, Imai T, Improvement of pharmaceutical propertied of zerumbone, a multifunctional compound, using cyclodextrin derivatives., Chem. Pharm. Bull., 68, 1117-1120 (2020)
5. Feng Y, Wan J, Chen B, Zhu Y, Firempong CK, Feng C, Imai T, Xu X, Yu J. In Vitro Metabolic Profiling of Periplogenin in Rat Liver Microsomes and its Associated Enzyme-kinetic Evaluation. Current Pharml Anal 　DOI : 10.2174/1573412915666190101101710 (2020).
6. Imai T, Bahar FG, Ohura K, Toda A. Effect of calcium on the hydrolysis activity of human butyrylcholinesterase.　 J Pharm Sci. 109(3), 1417-1420 (2020).
7. Ohura K., Igawa Y., Tanaka M., Matsumoto K., Kasahara A., Wada N., Kubota K., Uno Y., Imai T., Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in small intestine of cynomolgus monkey., Drug Metab. Dispos., 48(3), 146-152 (2020).
8. Hassan Md. M, Adhikari-Devkota A, Imai T, Devkota HP Zerumbone and Kaempferol Derivatives from the Rhizomes of Zingiber montanum (J. Koenig) Link ex A. Dietr. from Bangladesh, Separations, 6, 31 (2019).
9. Samir A, Ohura K, Bodor N, Imai T. Identification of major esterase involved in hydrolysis of soft anticholinergic (2R3’R-SGM) designed from glycopyrrolate in human and rat tissues. J Pharm Sci. 108, 2791-2797 (2019).
10. Inaba I, K. Ohura, Nakada Y., Imai T., Survey on the number of pharmacies storage seinnoside generic products and patient preference for their selection. [Japanese] Jpn. J. Drug Inform, 21, 1-8 (2019).
11. Imai T, Nakada Y, Ohura K, Comparative xtudy on hydrolysis activity in skin with liver and intestinr, and its aging relation of carvoxylesterase expression in cynomolgus monkewy and beagle dog., [Japanese], Yakugaku Zasshi, 139, 837-844 (2019).
12. Yamazaki T, Inui M, Hiemori K, Tomono S, Itoh M, Ichimonji I, Nakashima A, Takagi H, Biswas M, Izawa K, Kitaura J, Imai T, Sugiura N, Tateno H, Akashi-Takamura S., Receptor destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis., J Biol Chem, 294, 6659-6669 (2019).
13. Samir A, Kage A, Ohura K, Imai T, Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat. Xenobiotica, 49, 569-576, (2019).
14. Imai T, Introducing the Academy of Pharmaceutical Science and Technology, [Japanese], Yakugaku Zasshi, 139, 411-414 (2019).
15. Uno Y, Igawa Y, Tanaka M, Ohura K, Hosokawa M, Imai T, Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver. Xenobiotica, 49, 247-255 (2019).
16. Ishizaki Y, Furihata T, Oyama Y, Ohura K, Imai T, Hosokawa M, Akita H, Chiba K, Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies. Biol Pharm Bull., 41, 697-706 (2018).
17. Uno Y, Uehara S, Mahadhi HMD, Ohura K, Hosokawa M, Imai T. Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques. J Med Primatol., 47, 185-191 (2018).
18. Abdel-Daim A, Ohura K, Imai T. A novel quantification method for serine hydrolases in cellular expression system using fluorophosphonate-biotin probe. Eur J Pharm Sci., 114, 267-274 (2018).
19. Fujii M, Ohara R, Matsumi A, Ohura K, Koizumi N, Imai T, Watanabe Y. Effect of alcohol on skin permeation and metabolism of an ester-type prodrug in Yucatan micropig skin. Eur J Pharm Sci., 109, 280-287 (2017).
20. Imai T, Tanaka K, Yonemitsu T, Yakushiji Y, Ohura K., Elucidation of the Intestinal Absorption of para-Aminobenzoic Acid, a Marker for Dietary Intake. J Pharm Sci., 106, 2881-2888 (2017).
21. Samir A, Bodor N, Imai T. Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochem Pharmacol., 127, 82-89 (2017).
22. Ohura K, Nishiyama H, Saco S, Kurokawa K, Imai T. Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine. Drug Metab Dispos., 44, 1890-1898 (2016).
23. Igawa Y, Fujiwara S, Ohura K, Hirokawa T, Nishizawa Y, Uehara S, Uno Y, Imai T. Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes. Mol Pharm., 13, 3176-3186 (2016).
24. Imai T, Ariyoshi S, Ohura K, Sawada T, Nakada Y. Expression of Carboxylesterase Isozymes and Their Role in the Behavior of a Fexofenadine Prodrug in Rat Skin. J Pharm Sci., 105, 714-721 (2016).

中 原

1. 中原　広道, Langmuir単分子膜手法によるテトラジン誘導体と生体膜構成脂質との相互作用, Colloid & Interface Communication 48(1) (2023)23-26.
2. Hiromichi Nakahara, Masayori Hagimori, Kento Kannaka, Takahiro Mukai, Osamu Shibata, Inverse electron-demand Diels-Alder reactions of tetrazine and norbornene at the air-water interface, Colloids Surf. B Biointerfaces 211 (2022) 112333, DOI: 10.1016/j.colsurfb.2022.112333.
3. Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, Osamu Shibata, Interplay of long-chain tetrazine derivatives and biomembrane components at the air–water interface, Biophysics Rev. 3 (2022) 021303, DOI: 10.1063/5.0083352.
4. Cuong V. Nguyen, Chi M. Phan, Hiromichi Nakahara, Osamu Shibata, Ionic distribution of MgCl2 near the alcohol/water interface, J. Mol. Liq. 344 (2021) 117902, DOI: 10.1016/j.molliq.2021.117902.
5. Cuong V. Nguyen, Hiromichi Nakahara, Osamu Shibata, Chi M. Phan, Adsorption of sodium iodine at air/water interface, J. Mol. Liq. 298 (2020) 112076, DOI: 10.1016/j.molliq.2019.112076.
6. Hiroki Ideguchi, Yuya Takasaki, Shintaro Kondo, Mai Nakanose, Nana Teradahira, Yumeka Yamamoto, Umi Mouri, Hiromichi Nakahara, Solubilization of progesterone and its derivatives into gemini surfactant solutions, J. Oleo Sci. 69 (2020) 557-562, DOI: 10.5650/jos.ess20007.
7. Cuong V. Nguyen, Hiromichi Nakahara, Chi M. Phan, Surface potential of the air/water interface, J. Oleo Sci. 69 (2020) 519-528, DOI: 10.5650/jos.ess20024.
8. Hiromichi Nakahara, Marie Pierre Krafft, Osamu Shibata, How self-assembled nanodomains can impact the organization of a phospholipid monolayer: flower-like arrays, ChemPhysChem 21 (2020) 1966-1970, DOI: 10.1002/cphc.202000496.
9. Kento Kannaka, Kohei Sano, Hiromichi Nakahara, Masayuki Munekane, Masayori Hagimori, Toshihide Yamasaki, Takahiro Mukai, Inverse electron demand Diels–Alder reactions in the liposomal membrane accelerates release of the encapsulated drugs, Langmuir 36 (2020) 10750-10755, DOI: 10.1021/acs.langmuir.0c01525.
10. Hiromichi Nakahara, Muneaki Minamisono, Osamu Shibata, Fluidity of binary monolayers of semi-fluorinated and non-fluorinated fatty alcohols at the air−water interface, J. Fluorine Chem. 228 (2019) 109408, DOI: 10.1016/j.jfluchem.2019.109408.
11. Hiromichi Nakahara, Muneaki Minamisono, Osamu Shibata, Lateral interaction of cholesterol with a semifluorinated amphiphile at the air–water interface, Colloids Surf. B Biointerfaces181 (2019) 1035−1040, DOI: 10.1016/j.colsurfb.2019.06.072.
12. Hiromichi Nakahara, Ayami Nishino, Ayaka Tanaka, Yoshika Fujita, Osamu Shibata, Interfacial behavior of gemini surfactants with different spacer lengths in aqueous medium, Colloid Polym. Sci. 297 (2019) 183−189, DOI: 10.1007/s00396-018-4459-8.
13. Hiromichi Nakahara, Osamu Shibata, Miscibility of semifluorinated pentadecanol with DPPC at the air−water interface, Acc. Mater. Surf. Res. 3 (2018) 199−208.
14. Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, Osamu Shibata, Monolayers of a tetrazine-containing gemini amphiphile: Interplays with biomembrane lipids, Colloids Surf. B Biointerfaces 164 (2018) 1−10, DOI: 10.1016/j.colsurfb.2018.01.015.
15. Cuong V. Nguyen, Chi M. Phan, Hiromichi Nakahara, Osamu Shibata, Surface structure of sodium chloride solution, J. Mol. Liq. 248 (2017) 1039–1043, DOI: 10.1016/j.molliq.2017.10.138.
16. Hiromichi Nakahara, Hiroaki Nishizaka, Kensuke Iwasaki, Yu Otsuji, Mika Sato, Keisuke Matsuoka, Osamu Shibata, Role of the spacer of Gemini surfactants in solubilization into their micelles, J. Mol. Liq. 244 (2017) 499−505, DOI: 10.1016/j.molliq.2017.09.014.
17. Daiki Kobayashi, Hiromichi Nakahara, Osamu Shibata, Kei Unoura, Hideki Nabika, Interplay of Hydrophobic and Electrostatic Interactions between Polyoxometalates and Lipid Molecules, J. Phys. Chem. C 121 (2017) 12895−12902, DOI: 10.1021/acs.jpcc.7b01774.
18. Riku Kato, Hiromichi Nakahara, Osamu Shibata, Interfacial Properties of Binary Systems Composed of DPPC and Perfluorinated Double Long-Chain Salts with Divalent Counterions of Separate Electric Charge, J. Oleo Sci. 66 (2017) 479−489, DOI: 0.5650/jos.ess16208.
19. Shiv K. Sharma, Shanghao Li, Miodrag Micic, Jhony Orbulescu, Daniel Weissbart, Hiromichi Nakahara, Osamu Shibata, and Roger M. Leblanc, ‑Galactosidase Langmuir Monolayer at Air/X-gal Subphase Interface, J. Phys. Chem. B 120 (2016) 12279−12286, DOI: 10.1021/acs.jpcb.6b09020.
20. Chi M. Phan, Cuong V. Nguyen, Hiromichi Nakahara, Osamu Shibata, and Thanh V. Nguyen, Ionic Nature of a Gemini Surfactant at the Air/Water Interface, Langmuir 32 (2016) 12842−12847, DOI: 10.1021/acs.langmuir.6b03484.
21. Hiromichi Nakahara, Sannamu Lee, and Osamu Shibata, Interfacial Phenomena of Pulmonary Surfactant Preparations, In Encyclopedia of Biocolloid and Biointerface Science, Hiroyuki Ohshima, Ed., Wiley Inc., 2016, pp885-904, ISBN: 978-1-118-54276-7.
22. Hiromichi Nakahara and Osamu Shibata, Langmuir Monolayer Interaction of Perfluorooctylated Long-Chain Alcohols with Biomembrane Constituents, In Encyclopedia of Biocolloid and Biointerface Science, Hiroyuki Ohshima, Ed., Wiley Inc., 2016, pp597-608, ISBN: 978-1-118-54276-7.
23. Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, and Osamu Shibata, Interactions of a Tetrazine Derivative with Biomembrane Constituents: A Langmuir Monolayer Study, Langmuir 32 (2016) 6591−6599, DOI: 10.1021/acs.langmuir.6b00997.
24. 中原　広道, 人工調製肺サーファクタント製剤におけるフッ素化合物導入の可能性, Colloid & Interface Communication 41(2) (2016)21-24.
25. Hiromichi Nakahara, Fluidizing and Solidifying Effects of Perfluorooctylated Fatty Alcohols on Pulmonary Surfactant Monolayers. J. Oleo Sci. 65 (2016) 99−109, DOI: 10.5650/jos.ess15222.

鎌　内

1. Migita K, Moriyama T, Koguchi M, Honda K, Katsuragi T, Takano Y, Ueno S. Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin -induced diabetic neuropathy. Neurosci Lett. 452(2):200-3. (2009)
2. Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M. Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest. 118(12):4049-57. (2008)
3. Sakurada T, Komatsu T, Moriyama T, Sasaki M, Sanai K, Orito T, Sakurada C, Sakurada S. Effects of intraplantar injections of nociceptin and its N-terminal fragments on nociceptive and desensitized responses induced by capsaicin in mice. Peptides. 26(12):2505-12. (2005)
4. Moriyama T, Higashi T, Togashi K, Iida T, Segi E, Sugimoto Y, Tominaga T, Narumiya S, Tominaga M. Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain.17;1:3.(2005)
5. Tominaga M, Numazaki M, Iida T, Moriyama T, Togashi K, Higashi T, Murayama N, Tominaga T. Regulation mechanisms of vanilloid receptors.Novartis Found Symp. 261:4-12 (2004)
6. Dai Y, Moriyama T, Higashi T, Togashi K, Kobayashi K, Yamanaka H, Tominaga M, Noguchi K. Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J Neurosci. 24(18):4293-9. (2004)
7. Moriyama T, Iida T, Kobayashi K, Higashi T, Fukuoka T, Tsumura H, Leon C, Suzuki N, Inoue K, Gachet C, Noguchi K, Tominaga M. Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity. J Neurosci. 23(14):6058-62. (2003)
8. Sakurada T, Matsumura T, Moriyama T, Sakurada C, Ueno S, Sakurada S. Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice. Pharmacol Biochem Behav. 75(1):115-21. (2003)

髙　口

1. Koguchi H, Tahara M, Ogami S, Yamada T, Hayashi S, Yoshinaga Y, Hamasaki K, Kojima Y, Kaneshige S, Akishita M, Kamimura H. Prescription optimization for hospitalized elderly patients in community-based integrated care wards using a template for pharmaceutical intervention. Japanese Pharmacol. Ther. 49(2):221-228. (2021)
2. Koguchi H, Tahara M, Katsuki M, Takatsu H, Hayashi S, Yoshinaga Y, Kaneshige S, Akishita M, Kamimura H. Prescription optimization for hospitalized elderly patients in convalescence rehabilitation wards using a template for pharmaceutical intervention. Japanese Pharmacol. Ther. 48(11):1897-1903. (2020)
3. Koguchi H, Shimoyama M, Takatsu H, Shin K, Yamada T, Sakemi S, Mori H, Kaneshige S, Akishita M, Kamimura H. Study on prescription optimization for hospitalized elderly patients in general wards using a template for evaluating medicines brought to the hospital.Japanese Pharmacol. Ther. 47(8):1187-1193. (2019)
4. Hiroko Koguchi, Naomi Sugimoto, Tetsuya Mitsuyasu, Chiharu Matsunobu, Tomonori Shiratani, Tadahiro Ikeuchi, Susumu Kaneshige, Kentaro Ogata, Hidetoshi Kamimura. Risk evasion and the economic impact of pharmaceutical intervention by community pharmacists. Japanese Pharmacol. Ther. 47(3):375-382. (2019)
5. Hiroko Koguchi, Mineo Watanabe, Kiyoshi Ito, Wakano Ogawa, Futoshi Matsubara. Aminopeptidases from Bordetella pertussis and rat brain: Comparison between bacterial and mammalian proteins. Annual Report of Daiichi University of Pharmacy2017. 34:50-63 (2018)

今 井

今井輝子, Q14 加水分解酵素（エステラーゼなど）の主な基質について教えてください，[基本が身につく・考え方がわかる]エキスパートが教える薬物動態，編集：松元一明，月刊薬事　10月増刊号　Vol. 59, No. 14，じほう，　pp113-122, (2017)

今井輝子, 6-7 薬物相互作用 D. 代謝過程における薬物相互作用, E. 排泄過程における薬物相互作用, F.ファーマコダイナミクスにおける相互作用，製剤学, 改訂第7版, 編集:山本昌・岡本浩一・尾関哲也, 南江堂, pp415‒422, (2017).

今井輝子, 加水分解酵素（エステラーゼなど）の主な基質について教えてください，いまさら聞けない　薬物動態Q&A, 編集：松元一明・池谷修，月刊薬事　特集　Vol.58， No.4，じほう，pp79-81, (2016)

今井輝子, 第7章 ドラッグデリバリーシステム，2．プロドラッグとアンテドラッグ，生物薬剤学，改訂第3版，編集:林正弘・谷川原祐介，南江堂, pp199‒201, (2015)

中 原

溶存状態の分析化学，中島俊男，脇博彦，中原広道，柴田攻，長崎国際大学，長崎（2014），ISBN978-4-904962-04-6

界面活性剤の物理化学　理論と現象そして新概念　師井義清，中原広道，柴田攻，長崎国際大学，長崎（2013），ISBN978-4-904962-03-9

界面活性剤の選び方、使い方 事例集, 第5章 第3節　界面活性剤ミセルへの可溶化挙動解析，中原広道，技術情報協会，2019年7月31日，pp253−261，ISBN978-4-86104-753-4.

洗浄の事典, 1-27 ミセル形成、　6-7　cmc/クラフト点測定，朝倉書店，2022年10月1日，pp62−63，pp434−435，ISBN 978-4-254-25273-6、pp1−560.