科目ごとのオフィスアワーはシラバスを確認してください

錠剤・坐剤・貼付剤等の製剤は患者の薬物治療が有効かつ安全にそして利便性があるように設計されたものです。薬学で学ぶ化学・物理・生物等の知識を生かしDDS製剤の開発のための研究をしています。また、薬物－薬物間あるいは薬物－食物間相互作用等に関する体内動態の研究を行っています。

中 原

1. 中原　広道, Langmuir単分子膜手法によるテトラジン誘導体と生体膜構成脂質との相互作用, Colloid & Interface Communication 48(1) (2023)23-26.
2. Hiromichi Nakahara, Masayori Hagimori, Kento Kannaka, Takahiro Mukai, Osamu Shibata, Inverse electron-demand Diels-Alder reactions of tetrazine and norbornene at the air-water interface, Colloids Surf. B Biointerfaces 211 (2022) 112333, DOI: 10.1016/j.colsurfb.2022.112333.
3. Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, Osamu Shibata, Interplay of long-chain tetrazine derivatives and biomembrane components at the air–water interface, Biophysics Rev. 3 (2022) 021303, DOI: 10.1063/5.0083352.
4. Cuong V. Nguyen, Chi M. Phan, Hiromichi Nakahara, Osamu Shibata, Ionic distribution of MgCl2 near the alcohol/water interface, J. Mol. Liq. 344 (2021) 117902, DOI: 10.1016/j.molliq.2021.117902.
5. Cuong V. Nguyen, Hiromichi Nakahara, Osamu Shibata, Chi M. Phan, Adsorption of sodium iodine at air/water interface, J. Mol. Liq. 298 (2020) 112076, DOI: 10.1016/j.molliq.2019.112076.
6. Hiroki Ideguchi, Yuya Takasaki, Shintaro Kondo, Mai Nakanose, Nana Teradahira, Yumeka Yamamoto, Umi Mouri, Hiromichi Nakahara, Solubilization of progesterone and its derivatives into gemini surfactant solutions, J. Oleo Sci. 69 (2020) 557-562, DOI: 10.5650/jos.ess20007.
7. Cuong V. Nguyen, Hiromichi Nakahara, Chi M. Phan, Surface potential of the air/water interface, J. Oleo Sci. 69 (2020) 519-528, DOI: 10.5650/jos.ess20024.
8. Hiromichi Nakahara, Marie Pierre Krafft, Osamu Shibata, How self-assembled nanodomains can impact the organization of a phospholipid monolayer: flower-like arrays, ChemPhysChem 21 (2020) 1966-1970, DOI: 10.1002/cphc.202000496.
9. Kento Kannaka, Kohei Sano, Hiromichi Nakahara, Masayuki Munekane, Masayori Hagimori, Toshihide Yamasaki, Takahiro Mukai, Inverse electron demand Diels–Alder reactions in the liposomal membrane accelerates release of the encapsulated drugs, Langmuir 36 (2020) 10750-10755, DOI: 10.1021/acs.langmuir.0c01525.
10. Hiromichi Nakahara, Muneaki Minamisono, Osamu Shibata, Fluidity of binary monolayers of semi-fluorinated and non-fluorinated fatty alcohols at the air−water interface, J. Fluorine Chem. 228 (2019) 109408, DOI: 10.1016/j.jfluchem.2019.109408.
11. Hiromichi Nakahara, Muneaki Minamisono, Osamu Shibata, Lateral interaction of cholesterol with a semifluorinated amphiphile at the air–water interface, Colloids Surf. B Biointerfaces181 (2019) 1035−1040, DOI: 10.1016/j.colsurfb.2019.06.072.
12. Hiromichi Nakahara, Ayami Nishino, Ayaka Tanaka, Yoshika Fujita, Osamu Shibata, Interfacial behavior of gemini surfactants with different spacer lengths in aqueous medium, Colloid Polym. Sci. 297 (2019) 183−189, DOI: 10.1007/s00396-018-4459-8.
13. Hiromichi Nakahara, Osamu Shibata, Miscibility of semifluorinated pentadecanol with DPPC at the air−water interface, Acc. Mater. Surf. Res. 3 (2018) 199−208.
14. Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, Osamu Shibata, Monolayers of a tetrazine-containing gemini amphiphile: Interplays with biomembrane lipids, Colloids Surf. B Biointerfaces 164 (2018) 1−10, DOI: 10.1016/j.colsurfb.2018.01.015.
15. Cuong V. Nguyen, Chi M. Phan, Hiromichi Nakahara, Osamu Shibata, Surface structure of sodium chloride solution, J. Mol. Liq. 248 (2017) 1039–1043, DOI: 10.1016/j.molliq.2017.10.138.
16. Hiromichi Nakahara, Hiroaki Nishizaka, Kensuke Iwasaki, Yu Otsuji, Mika Sato, Keisuke Matsuoka, Osamu Shibata, Role of the spacer of Gemini surfactants in solubilization into their micelles, J. Mol. Liq. 244 (2017) 499−505, DOI: 10.1016/j.molliq.2017.09.014.
17. Daiki Kobayashi, Hiromichi Nakahara, Osamu Shibata, Kei Unoura, Hideki Nabika, Interplay of Hydrophobic and Electrostatic Interactions between Polyoxometalates and Lipid Molecules, J. Phys. Chem. C 121 (2017) 12895−12902, DOI: 10.1021/acs.jpcc.7b01774.
18. Riku Kato, Hiromichi Nakahara, Osamu Shibata, Interfacial Properties of Binary Systems Composed of DPPC and Perfluorinated Double Long-Chain Salts with Divalent Counterions of Separate Electric Charge, J. Oleo Sci. 66 (2017) 479−489, DOI: 0.5650/jos.ess16208.
19. Shiv K. Sharma, Shanghao Li, Miodrag Micic, Jhony Orbulescu, Daniel Weissbart, Hiromichi Nakahara, Osamu Shibata, and Roger M. Leblanc, ‑Galactosidase Langmuir Monolayer at Air/X-gal Subphase Interface, J. Phys. Chem. B 120 (2016) 12279−12286, DOI: 10.1021/acs.jpcb.6b09020.
20. Chi M. Phan, Cuong V. Nguyen, Hiromichi Nakahara, Osamu Shibata, and Thanh V. Nguyen, Ionic Nature of a Gemini Surfactant at the Air/Water Interface, Langmuir 32 (2016) 12842−12847, DOI: 10.1021/acs.langmuir.6b03484.
21. Hiromichi Nakahara, Sannamu Lee, and Osamu Shibata, Interfacial Phenomena of Pulmonary Surfactant Preparations, In Encyclopedia of Biocolloid and Biointerface Science, Hiroyuki Ohshima, Ed., Wiley Inc., 2016, pp885-904, ISBN: 978-1-118-54276-7.
22. Hiromichi Nakahara and Osamu Shibata, Langmuir Monolayer Interaction of Perfluorooctylated Long-Chain Alcohols with Biomembrane Constituents, In Encyclopedia of Biocolloid and Biointerface Science, Hiroyuki Ohshima, Ed., Wiley Inc., 2016, pp597-608, ISBN: 978-1-118-54276-7.
23. Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, and Osamu Shibata, Interactions of a Tetrazine Derivative with Biomembrane Constituents: A Langmuir Monolayer Study, Langmuir 32 (2016) 6591−6599, DOI: 10.1021/acs.langmuir.6b00997.
24. 中原　広道, 人工調製肺サーファクタント製剤におけるフッ素化合物導入の可能性, Colloid & Interface Communication 41(2) (2016)21-24.
25. Hiromichi Nakahara, Fluidizing and Solidifying Effects of Perfluorooctylated Fatty Alcohols on Pulmonary Surfactant Monolayers. J. Oleo Sci. 65 (2016) 99−109, DOI: 10.5650/jos.ess15222.

髙　口

1. Koguchi H, Tahara M, Ogami S, Yamada T, Hayashi S, Yoshinaga Y, Hamasaki K, Kojima Y, Kaneshige S, Akishita M, Kamimura H. Prescription optimization for hospitalized elderly patients in community-based integrated care wards using a template for pharmaceutical intervention. Japanese Pharmacol. Ther. 49(2):221-228. (2021)
2. Koguchi H, Tahara M, Katsuki M, Takatsu H, Hayashi S, Yoshinaga Y, Kaneshige S, Akishita M, Kamimura H. Prescription optimization for hospitalized elderly patients in convalescence rehabilitation wards using a template for pharmaceutical intervention. Japanese Pharmacol. Ther. 48(11):1897-1903. (2020)
3. Koguchi H, Shimoyama M, Takatsu H, Shin K, Yamada T, Sakemi S, Mori H, Kaneshige S, Akishita M, Kamimura H. Study on prescription optimization for hospitalized elderly patients in general wards using a template for evaluating medicines brought to the hospital.Japanese Pharmacol. Ther. 47(8):1187-1193. (2019)
4. Hiroko Koguchi, Naomi Sugimoto, Tetsuya Mitsuyasu, Chiharu Matsunobu, Tomonori Shiratani, Tadahiro Ikeuchi, Susumu Kaneshige, Kentaro Ogata, Hidetoshi Kamimura. Risk evasion and the economic impact of pharmaceutical intervention by community pharmacists. Japanese Pharmacol. Ther. 47(3):375-382. (2019)
5. Hiroko Koguchi, Mineo Watanabe, Kiyoshi Ito, Wakano Ogawa, Futoshi Matsubara. Aminopeptidases from Bordetella pertussis and rat brain: Comparison between bacterial and mammalian proteins. Annual Report of Daiichi University of Pharmacy2017. 34:50-63 (2018)

中 原

溶存状態の分析化学，中島俊男，脇博彦，中原広道，柴田攻，長崎国際大学，長崎（2014），ISBN978-4-904962-04-6

界面活性剤の物理化学　理論と現象そして新概念　師井義清，中原広道，柴田攻，長崎国際大学，長崎（2013），ISBN978-4-904962-03-9

界面活性剤の選び方、使い方 事例集, 第5章 第3節　界面活性剤ミセルへの可溶化挙動解析，中原広道，技術情報協会，2019年7月31日，pp253−261，ISBN978-4-86104-753-4.

洗浄の事典, 1-27 ミセル形成、　6-7　cmc/クラフト点測定，朝倉書店，2022年10月1日，pp62−63，pp434−435，ISBN 978-4-254-25273-6、pp1−560. 

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