薬学部健康・環境衛生学講座分析化学分野
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| スタッフ | 主な担当科目 | オフィスアワー |
|---|---|---|
| 教授 藤井 清永 (博士(薬学)) | 分析化学Ⅲ 構造解析学 基礎物理学 生命薬学実習Ⅱ 基礎実習 |
木曜日 13:30～16:30 不在の場合はメールにて対応 |
分析化学、特に分離分析、質量分析に特化して、生体分子や医薬品に対する分析手法の開発とその応用を試みています。
- Perfluorooctanoic acid (PFOA) as a stimulator of estrogen receptor-negative breast cancer MDA-MB-231 cell aggressiveness: Evidence for involvement of fatty acid 2-hydroxylase (FA2H) in the stimulated cell migration. Sakai G, Hirao-Suzuki M, Koga T, Kobayashi T, Kamishikiryo J, Tanaka M, Fujii K, Takiguchi M, Sugihara N, Toda A, Takeda S. J Toxicol Sci. 2022;47(4):159-168. doi: 10.2131/jts.47.159. PMID: 35370244.
- Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma. Sakai H, Kimura H, Otsubo K, Miyazawa T, Marushima H, Kojima K, Chosokabe M, Furuya N, Koike J, Fujii K, Nishimura T, Nakamura H, Saji H. Mol Clin Oncol. 2022 Jan;16(1):22. doi: 0.3892/mco.2021.2455. Epub 2021 Nov 30. PMID: 34909200.
- Discovery of a highly potent and selective degrader targeting hematopoietic prostaglandin D synthase via in silico design. Yokoo H, Shibata N, Endo A, Ito T, Yanase Y, Murakami Y, Fujii K, Hamamura K, Saeki Y, Naito M, Aritake K, Demizu Y. J Med Chem. 2021 Nov 11;64(21):15868-15882. doi: 10.1021/acs.jmedchem.1c01206. Epub 2021 Oct 15. PMID: 34652145.
- Protein co-expression network-based profiles revealed from laser-microdissected cancerous cells of lung squamous-cell carcinomas. Nishimura T, Fujii K, Nakamura H, Naruki S, Sakai H, Kimura H, Miyazawa T, Takagi M, Furuya N, Marko-Varga G, Kato H, Saji H. Sci Rep. 2021 Oct 12;11(1):20209. doi: 10.1038/s41598-021-99695-x. PMID: 34642392.
- Development of a hematopoietic prostaglandin D synthase-degradation inducer. Yokoo H, Shibata N, Naganuma M, Murakami Y, Fujii K, Ito T, Aritake K, Naito M, Demizu Y. ACS Med Chem Lett. 2021 Jan 14;12(2):236-241. doi: 10.1021/acsmedchemlett.0c00605. eCollection 2021 Feb 11. PMID: 33603969.
- Hepatocyte MKK7 contributes to restoration of the liver parenchyma following injury. Ooshio T, Yamamoto M, Fujii K, Xin B, Watanabe K, Goto M, Okada Y, Suzuki A, Penninger JM, Nishina H, Nishikawa Y. Hepatology. 2021 Jun;73(6):2510-2526. doi: 10.1002/hep.31565. Epub 2021 May 28. PMID: 32969030.
- A proteogenomic profile of early lung adenocarcinomas by protein co-expression network and genomic alteration analysis. Nishimura T, Nakamura H, Tan KT, Zhuo DW, Fujii K, Koizumi H, Naruki S, Takagi M, Furuya N, Kato Y, Chen SJ, Kato H, Saji H. Sci Rep. 2020 Aug 12;10(1):13604. doi: 10.1038/s41598-020-70578-x. PMID: 32788598.
- Disease-related cellular protein networks differentially affected under different EGFR mutations in lung adenocarcinoma. Nishimura T, Nakamura H, Yachie A, Hase T, Fujii K, Koizumi H, Naruki S, Takagi M, Matsuoka Y, Furuya N, Kato H, Saji H. Sci Rep. 2020 Jul 2;10(1):10881. doi: 10.1038/s41598-020-67894-7. PMID: 32616892.
- Identification of key modules and hub genes for small-cell lung carcinoma and large-cell neuroendocrine lung carcinoma by weighted gene co-expression network analysis of clinical tissue-proteomes. Nakamura H, Fujii K, Gupta V, Hata H, Koizumu H, Hoshikawa M, Naruki S, Miyata Y, Takahashi I, Miyazawa T, Sakai H, Tsumoto K, Takagi M, Saji H, Nishimura T. PLoS One. 2019 Jun 5;14(6):e0217105. doi: 10.1371/journal.pone.0217105. eCollection 2019. PMID: 31166966.
- Emergence of the dedifferentiated phenotype in hepatocyte-derived tumors in mice: roles of oncogene-induced epigenetic alterations. Watanabe K, Yamamoto M, Xin B, Ooshio T, Goto M, Fujii K, Liu Y, Okada Y, Furukawa H, Nishikawa Y. Hepatol Commun. 2019 Feb 25;3(5):697-715. doi: 10.1002/hep4.1327. eCollection 2019 May. PMID: 31061957.
