科目ごとのオフィスアワーはシラバスを確認してください

1. 化学物質による神経科学的検討と行動薬理学的研究
2. アレルギー疾患における生体内生理活性物質の役割
3. Selenbp1タンパク質の機能解析と疾患への寄与に関する研究
4. 食品成分の排尿機能に対する作用とその作用機序に関する研究
5. QOL改善薬、特に排尿障害治療薬・予防薬の開発に関する研究
6. 環境因子（エンリッチ環境・非麻薬性中枢性鎮咳薬）の脳に対する作用とその作用機序に関する研究
7. POPsや内分泌撹乱物質の生体に及ぼす影響
8. 病棟に於ける様々な服薬指導業務の統計学的解析
9. 地域医療および地域保健における薬剤師の役割に関する研究
10. う蝕予防セルフケアの普及を目指したフッ化物利用の薬局における情報提供の効果
11. 環境化学物質の分析化学的研究とヒトへの健康影響評価
    

[原著論文]

1. Dimethylglycine, a methionine metabolite, participates in the suppressive effect of methionine on 1-fluoro-2,4-dinitrobenzene-induced dermatitis. Koga T, Inoue K, Hirayama F, Hiromura M, Fujii K, Ishii Y, Hirao-Suzuki M, Takeda S, Toda A, Soeda F. Biol. Pharm. Bull. 2023, in press doi: 10.1248/bpb.b23-00098. Online ahead of print.
2. Hachimijiogan, a Traditional Herbal Medicine, Modulates Adipose Cell Function and Ameliorates Diet-induced Obesity and Insulin Resistance in Mice. Kagawa S, Tanabe K, Hiromura M, Ogawa K, Koga T, Maeda T, Amo-Shiinoki K, Ochi H, Ichiki Y, Fukuyama S, Suzuki S, Suizu N, Ohmine T, Hamachi S, Tsuneki H, Okuya S, Sasaoka T, Tanizawa Y, Nagashima F. Front. Pharmacol. 2023, 14:1167934.
3. α-Lipoic acid eliminates dioxin-induced offspring sexual immaturity by improving abnormalities in folic acid metabolism. Yuan M, Sano H, Nishino T, Chen H, Li RS, Matsuo Y, Nishida K, Koga T, Takeda T, Tanaka Y, Ishii Y. Biochem. Pharmacol. 2023, 210:115490.
4. Effects of cloperastine, a non-narcotic antitussive, on the expression of GIRK channels in the brain of methamphetamine-induced hyperactive mice. Soeda F, Kinoshita M, Fujieda Y, Takahama K. Indian J. Physiol. Pharmacol., 2023, 67:57-63.
5. Profiles and determinants of dicofol, endosulfans, mirex, and toxaphenes in breast milk samples from 10 prefectures in Japan Profiles and determinants of dicofol, endosulfans, mirex, and toxaphenes in breast milk samples from 10 prefectures in Japan. Fujii Y, Harada KH, Ito Y, Yoshitake M, Matsunobu C, Kato Y, Ohta C, Koga N, Kimura O, Endo T, Koizumi A, Haraguchi K. Chemosphere. 2023, 311:137002.
6. Perfluorooctanoic acid (PFOA) as a stimulator of estrogen receptor-negative breast cancer MDA-MB-231 cell aggressiveness: Evidence for involvement of fatty acid 2-hydroxylase (FA2H) in the stimulated cell migration. Sakai G, Hirao-Suzuki M, Koga T, Kobayashi T, Kamishikiryo J, Tanaka M, Fujii K, Takiguchi M, Sugihara N, Toda A, Takeda S. J Toxicol Sci. 2022, 47:159-168.
7. Levels of Short- and Medium-Chain Chlorinated Paraffins in Edible Insects and Implications for Human Exposure. McGrath TJ, Fujii Y, Jeong Y, Bombeke J, Covaci A, Poma G. Environ Sci Technol. 2022, 56(18):13212-13221.
8. Effects of enriched environment on micturition activity in freely moving C57BL/6J mice. Soeda F, Toda A, Masuzaki K, Miki R, Koga T, Fujii Y, Takahama K. Low Urin Tract Symptoms., 2021, 13:400-409.
9. Micturition function of freely moving BALB/c mice and their effects on rearing environment and neurogenesis inhibitor. Soeda F, Toda A, Masuzaki K, Honda A, Moriyama S, Tashiro A, Kimura I, Kudo S, Sato A, Hashimoto T, Wakayama K, Koga T, Kobuke Y, Takahama K. J Jpn Continence Soc., 2021, 31: 404-410.
10. Methionine is a key regulator in the onset of atopic dermatitis in NC/Nga mice. Koga T, Hirayama F, Satoh T, Ishii Y, Kashige N, Hiromura M, Soeda F, Toda A. BPB Reports., 2021, 4:47-54.
11. Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice. Foreman JE, Koga T, Kosyk O, Kang BH, Zhu X, Cohen SM, Billy LJ, Sharma AK, Amin S, Gonzalez FJ, Rusyn I, Peters JM. Toxicol Sci., 2021, 183:70-80.
12. Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice. Foreman JE, Koga T, Kosyk O, Kang BH, Zhu X, Cohen SM, Billy LJ, Sharma AK, Amin S, Gonzalez FJ, Rusyn I, Peters JM. Toxicol Sci., 2021,183:81-92.
13. Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for the Treatment or Prevention of Alcoholic Liver Disease.　Koga T, Peters JM. Biol Pharm Bull., 2021, 44:1598-1606.
14. Ablation of Selenbp1 Alters Lipid Metabolism via the Pparα Pathway in Mouse Kidney. Song Y, Kurose A, Li R, Takeda T, Onomura Y, Koga T, Mutoh J, Ishida T, Tanaka Y, Ishii Y. Int J Mol Sci., 2021, 22:5334.
15. Estimation of dietary intake and sources of organohalogenated contaminants among infants: 24-h duplicate diet survey in Fukuoka, Japan. Fujii Y, Poma G, Malarvannan G, Soeda F, Toda A, Haraguchi K, Covaci A. Environ Res. 2021, 195:110745
16. Identification of novel halogenated naturally occurring compounds in marine biota by high-resolution mass spectrometry and combined screening approaches. Belova L, Fujii Y, Cleys P, Śmiełowska M, Haraguchi K, Covaci A. Environ Pollut. 2021 Nov 15;289:117933.
17. Effects of tipepidine on MK-801-induced cognitive impairment in mice. Miki R, Honda I, Hamasaki R, Kawahara R, Soeda F, Shirasaki T, Misumi S, Takahama K. Brain Res., 2019, 1710:230-236.
18. Levels and profiles of long-chain perfluoroalkyl carboxylic acids in Pacific cod from 14 sites in the North Pacific Ocean. Fujii Y, Tuda H, Kato Y, Kimura O, Endo T, Harada KH, Koizumi A, Haraguchi K. Environ Pollut. 2019, 247:312-31
19. Fatty acid 2-hydroxylase (FA2H) as a stimulatory molecule responsible for breast cancer cell migration. Hirao-Suzuki M, Koga T, Sakai G, Kobayashi T, Ishii Y, Miyazawa H, Takiguchi M, Sugihara N, Toda A, Ohara M, Takeda S. Biochem Biophys Res Commun., 2020, 531:215-222.
20. Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation. Hirao-Suzuki M, Takeda S, Koga T, Takiguchi M, Toda A. J. Toxicol. Sci., 2020;45:227-236.
21. 雌マウス肝臓におけるセレン結合性タンパク質（SelenBP）の発現と2,3,7,8-Tetrachlorodibenzo-p-dioxin被誘導性：SelenBP1欠損動物を用いた検討. 宋 穎霞, 藤本 景子, 黒瀬 厚, 石田 卓巳, 古賀 貴之, 李 任時, 武田 知起, 武知 進士, 山田 英之, 田中 嘉孝, 石井 祐次. 福岡醫學雜誌, 2019, 110, 128-132.
22. Deletion of GIRK2 subunit containing GIRK channels of neurons expressing dopamine transporter decrease immobility time on forced swimming in mice. Honda I, Araki K, Honda S, Soeda F, Shin MC, Misumi S, Yamamura KI, Takahama K. Neurosci Lett., 2018, 665:140-146.
23. Contamination trends and factors affecting the transfer of hexabromocyclododecane diastereomers, tetrabromobisphenol A, and 2,4,6-tribromophenol to breast milk in Japan. Fujii Y, Kato Y, Masuda N, Harada KH, Koizumi A, Haraguchi K. Environ Pollut. 2018, 237:936-943.
24. Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration. Takeda T, Komiya Y, Koga T, Ishida T, Ishii Y, Kikuta Y, Nakaya M, Kurose H, Yokomizo T, Shimizu T, Uchi H, Furue M, Yamada H. J Biol Chem., 2017, 292:10586-10599.
25. α-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis. Takeda T, Matsuo Y, Nishida K, Fujiki A, Hattori Y, Koga T, Ishii Y, Yamada H. J Toxicol Sci., 2017, 42:13-23.
26. 小武家　優子、薬学教育における在宅医療教育の現状とその課題「教育用在宅症例作成ワーキンググループ」活動を通じて、薬学雑誌; 137 (8): 935-940 (2017)
27. Long-term trends in dietary intake of perfluoroalkyl carboxylic acids in relation to their serum concentration in two regions in Japan from 1979 to 2011. Fujii Y, Harada KH, Haraguchi K, Koizumi A. Chemosphere. 2017, 165-174.
28. Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy. Koga T, Yao PL, Goudarzi M, Murray IA, Balandaram G, Gonzalez FJ, Perdew GH, Fornace AJ Jr, Peters JM. J Biol Chem., 2016, 291:25255-25263.
29. Centrally acting non-narcotic antitussives prevent hyperactivity in mice: Involvement of GIRK channels. Soeda F, Fujieda Y, Kinoshita M, Shirasaki T, Takahama K. Pharmacol Biochem Behav., 2016, 144:26-32.
30. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Kawaura K, Ogata Y, Honda S, Soeda F, Shirasaki T, Takahama K. Behav Brain Res., 2016, 302: 269-278.
31. 笹原明日香、小武家優子、村井未来、大光正男、吉武毅人、中途視覚障害者における薬剤使用の実態調査、社会薬学; 35巻 2号: 69-79 (2016)
32. Tipepidine increases dopamine level in the nucleus accumbens without methamphetamine-like behavioral sensitization. Hamao K, Kawaura K, Soeda F, Hamasaki R, Shirasaki T, Takahama K. Behav Brain Res., 2015, 284:118-124.
33. Novel antitussive effect of suplatast tosilate in guinea pigs. Zhou JR, Syono R, Fukumi S, Kimoto K, Shirasaki T, Soeda F, Takahama K. Pharmacology, 2015, 95: 36-41.
34. 飯田浩子、安藤伸一郎、坂本潤治、重光美希、小武家優子、大光正男、湯川栄二、吉武毅人、薬剤師のフィジカルアセスメント実践に有効なセミナープログラム構築に向けた意識調査、社会薬学; 34 巻2号: 132-140 (2015)
35. Long-chain perfluoroalkyl carboxylic acids in Pacific cods from coastal areas in northern Japan: a major source of human dietary exposure. Fujii Y, Sakurada T, Harada KH, Koizumi A, Kimura O, Endo T, Haraguchi K. Environ Pollut. 2015 199:35-41.
36. Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans. Fujii Y, Niisoe T, Harada KH, Uemoto S, Ogura Y, Takenaka K, Koizumi A. J Occup Health. 2015;57(1):1-12.
37. Cloperastine rescues impairment of passive avoidance response in mice prenatally exposed to diethylstilbestrol. Soeda F, Hirakawa E, Inoue M, Shirasaki T, Takahama K. Environ Toxicol., 2014, 29:216-225.
38. Characterization of neural estrogen signaling and neurotrophic changes in the accelerated ovarian failure mouse model of menopause. Van Kempen TA, Gorecka J, Gonzalez AD, Soeda F, Milner TA, Waters EM. Endocrinology, 2014, 155:3610-3623.
39. Cholinergic EPSCs and their potentiation by bradykinin in single paratracheal ganglion neurons attached with presynaptic boutons. Zhou JR, Shirasaki T, Soeda F, Takahama K. J Neurophysiol., 2014, 112:933-941.
40. Role of the critical period in sex and brain differentiation: learning from dioxin-induced disorders in next generations. Yamada H, Takeda T, Koga T, Ishii Y. Yakugaku Zasshi. 2014, 134:529-35.
41. 吉田健、小武家優子、大光正男、吉武毅人、処方せん応需薬局における待ち時間予測に関する検討、社会薬学; 33 巻2 号: 61-66 (2014)
42. Dietary exposure to phenolic and methoxylated organohalogen contaminants in relation to their concentrations in breast milk and serum in Japan. Fujii Y, Nishimura E, Kato Y, Harada KH, Koizumi A, Haraguchi K. Environ Int. 2014, 63:19-25.
43. PPARβ/δ modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity. Goudarzi M1, Koga T1, Khozoie C, Mak TD, Kang BH, Fornace AJ Jr and Peters JM. Toxicology, 2013; 311: 87-98.1Equally contributing authors.
44. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D ₂receptor-mediated inward rectifying K ⁺current. Hamasaki R, Shirasaki T, Soeda F, Takahama K. Neuroscience, 2013, 252:24-34.
45. Effect of tipepidine with novel antidepressant-like action on c-fos-like protein expression in rat brain. Kawahara R, Soeda F, Kawaura K, Honda S, Miki R, Noguchi T, Shirasaki T, Takahama K. Brain Res., 2013, 1513:135-142.
46. 小武家 優子, 山本 香織, 馬郡 麻衣, 杉野 絵里, 吉田 健, 吉武 毅人、災害サイクルからみた東日本大震災における薬剤師支援業務の変化―福岡県薬剤師会会員ボランティア派遣者の質問紙調査から―、九州薬学会会報; 67: 73-76 (2013)
47. Occurrence of perfluorinated carboxylic acids (PFCAs) in personal care products and compounding agents. Fujii Y, Harada KH, Koizumi A. Chemosphere. 2013, 93(3):538-44
48. Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid. Koga T, Ishida T, Takeda T, Ishii Y, Uchi H, Tsukimori K, Furue M, and Yamada H. PLOS ONE, 2012; 7: e40322.
49. Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test. Kawaura K, Miki R, Urashima Y, Kawahara R, Soeda F, Shirasaki T, Takahama K. Behav Brain Res., 2012; 226:381-385.
50. Analysis of perfluoroalkyl carboxylic acids in composite dietary samples by gas chromatography/mass spectrometry with electron capture negative ionization. Fujii Y, Harada KH, Koizumi A. Environ Sci Technol. 2012; 46(20):11235-42
51. Levels and profiles of long-chain perfluorinated carboxylic acids in human breast milk and infant formulas in East Asia. Fujii Y, Yan J, Harada KH, Hitomi T, Yang H, Wang P, Koizumi A. Chemosphere. 2012, 86(3):315-21.
52. The effect of aging and an ovariectomy operation on the level of phosphorylated CaM kinase II in the hippocampus of female mice prenatally exposed to diethylstilbestrol. Soeda F, Nagata M, Kaitsuka T, Shirasaki T, Takahama K. Environ Toxicol Pharmacol., 2011, 31:496-499.
53. Is the GIRK channel a possible target in the development of a novel therapeutic drug of urinary disturbance? Yamamoto G, Soeda F, Shirasaki T, Takahama K. Yakugaku Zasshi. 2011, 131:523-532.
54. Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test. Kawaura K, Miki R, Urashima Y, Honda S, Shehata AM, Soeda F, Shirasaki T, Takahama K. Eur J Pharmacol., 2011, 651:106-108.
55. The potent inhibitory effect of tipepidine on marble-burying behavior in mice. Honda S, Kawaura K, Soeda F, Shirasaki T, Takahama K. Behav Brain Res., 2011, 216:308-312.
56. Antidepressant-like effect of centrally acting non-narcotic antitussive caramiphen in a forced swimming test. Kawaura K, Miki R, Shima E, Honda S, Soeda F, Shirasaki T, Takahama K. Neuroscience Lett., 2010, 481:188-190.
57. An enriched environment mitigates the brain-disruptive effects of prenatal diethylstilbestrol exposure in mice. Soeda F, Tanaka A, Shirasaki T, Takahama K. Neuroscience,2010, 169:223-228.

• 「衛生薬学−基礎・予防・臨床 改訂第4版」編集／今井浩孝，小椋康光：分担執筆／副田二三夫, 古賀貴之 南江堂, 東京（2023）
• 医学のあゆみ「有機フッ素化合物（PFAS）への曝露とヒト健康リスク; 特集 環境化学物質が人体へ与える影響」原田浩二, 藤谷倫子, 藤井由希子285(2) p144-149
• 「予防薬学としての衛生薬学−健康と環境− 第4版」監修/吉原新一，編集／山野茂，戸田晶久：分担執筆／副田二三夫, 小武家優子 廣川書店, 東京（2022）
• 「薬学生のための英語 2」著／日本薬学英語研究会, コラム執筆(専門職連携教育(IPE)について思うこと)／小武家優子，成美堂, 東京（2019）
• 「よくわかる薬学分析化学　第２版」分担執筆／藤井由希子 廣川書店 （2019）
• 「PBLケーススタディー薬物治療学演習―実務実習から在宅医療を見据えて―」編集／吉武毅人, 大澤友二：分担執筆(序章0-8 在宅医療)／小武家優子，廣川鉄男事務所, 東京（2018）
• Handbook of dietary and nutritional aspects of human breast milk -Prevention, treatment and toxicity, Chapter5, Adverse factors on lactation or composition of breast milk, Comparing pesticides in human breast milk from China, Korea and Japan Academic Publishers, Authors: Koizumi A, Harada K, Fujii Y. (2013)
• 「Pharmacology and Therapeutics of Cough」 Central Mechanism III: Neuronal mechanisms of action of centrally acting antitussives using electrophysiological and neurochemical study approaches. Editors: Kian Fan Chung, John Widdicombe; Authors: Takahama K, Shirasaki T, Soeda F. Springer Berlin Heidelberg (2009)
• 「排尿障害プラクティス」脳梗塞に伴う排尿障害のGIRKチャネル阻害作用をもつ薬物による改善作用－動物モデルでの検討．高濱和夫, 山本巌, 門久大介, 白崎哲哉, 副田二三夫 15(4):38-43, メディカルレビュー社 (2008)
• 「脳21-脳内GIRK チャネルとくすり-」高濱和夫, 白崎哲哉, 副田二三夫, 山本巌 9(3):90-96, 金芳堂 (2006)

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